Comparison of the efficacy of the aromatase inhibitor letrozole and clomiphene citrate as adjuvants to recombinant follicle-stimulating hormone in controlled ovarian hyperstimulation: a prospective, randomized, blinded clinical trial. My FS seemed quite disappointed with the size of my follicle, but said it should hopefully grow 2mm per day and should be 18-20mm by Thursday (CD14). This did not differ significantly from the anovulatory group. :/. If you are iui, this might be why they are wanting them to grow faster? Good luck to you!! If so, good luck tomorrow! At the time of the ultra-sound, the mean diameter of the follicle was calculated from measurements in two perpendicular planes for any fol-liclesmeasuringgreaterthan14mm.Thiswasrecordedalong Barroso G, Menocal G, Felix H, Rojas-Ruiz JC, Arslan M, Oehninger S. Fertil Steril. Nevertheless, clinical investigation of the drug in infertile women has been generally limited to 5 days of treatment at doses of 2.57.5mg daily. I responded super quickly to my normal dosage of Letrozole for some reason. I have only had a natural LH surge one out of three cycles on Letrozole. Once follicles are in active growth, they can grow 1-2mm per day. Or is that 4mm difference just too much? He can up your dose of gonal f and start u on cd 3. PMC Or is it possible for the lead to grow to 22mm, the next one gets to 18mm and then those two ovulate together? 9 Create an account or log in to participate. The last three years has been one heart break after another. . Yen, G. A. Laughlin, and A. J. Morales, Interface between extra- and intraovarian factors in polycystic ovarian syndrome, Annals of the New York Academy of Sciences, vol. Report. 0 Sperm Preparation and Insemination After 2-3 days of abstinence, semen samples were obtained through masturbation and then liquefied for 15-20 minutes. Letrozole has become an important tool in our armamentarium for treating infertility, yet surprisingly little effort has been devoted toward optimizing its effectiveness. Follicle Size On Day 14. 5 Copyright 2012 American Society for Reproductive Medicine. My RE had me on 7 days for my first round, and then my ob had me on 5 this past round, both 10mg. 27/05/2020 00:35, Thanks. National Library of Medicine Praying something grows. No such luck for me. ?i am going back again on cd 15.i was taking letrozole 5 mg on cd 2 - 6. Follicle size on letrozole So Sophie Sat, Apr 23 Baby 2 on the way I went in for a follicle ultrasound today cd 11 and had 2 follicles measuring 11 x 11 and 12 x 12.will any of these follicles grow to 18 mm ? Bethesda, MD 20894, Web Policies Praying to all my guardian angels out there. Intervention: In addition to receiving letrozole (5 mg) daily from the third to the seventh day of the menstrual cycle, the intervention group will be treated with Iranian medicine product containing asparagus root syrup twice a day, 30 cc each morning and evening during 2 ovulation stimulation cycles from the first to the fourteenth day of the menstrual cycle. Did your follicles continue to grow? I had a 21mm follicle showing on ultrasound last Wednesday (14th). Scan on CD 11 showed a 14.3mm on the right, a 10.6 and 9.9 on the left. Do you think there's still any hope for some to grow bigger by then? 26222629, 1998. Kansas City. Find advice, support and good company (and some stuff just for fun). There were no statistically significant differences in follicular diameter between the three groups until cycle day seven (table 3).Compared to the natural group, both the letrozole 2.5 mg/day and 5 mg/day groups had significantly more follicles 10 mm on day 7 (p = 0.0001 and 0.0001, respectively), more follicles 12 mm on days 9-11 (p . Im confused how this works. I'm really curious to find out what size you all general receive your hcg trigger shot? And yea follicles can get really big and become harmful cycsts but its not usually the case. I would hate to see you go through this and miss your opportunity this cycle. Often, I don't trigger until cycle day 18, and ovulate between cycle day 19-20. I've been seeing the weight management Dr's at my primary Dr's office and they want to do gastric sleeve but last time I had an abdominal surgery it went VERY wrong and I almost died. Use of this site is subject to our terms of use and privacy policy. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. 20, no. Now on progesterone til I test. Femara works in a similar way to Clomid, suppressing estrogen leading to an increase in FSH production, which stimulates the ovarian follicles to mature and triggers ovulation. Baby dust, Oct17bride- Thanks for respoding. I had 3 IUIs and each time I triggered and then ovulated. Nevertheless, we believe that high doses of this drug can and should be employed, particularly in women inadequately responsive to lower doses. I'm wondering if that follicle will just keep growing and I can expect to ovulate late, or is it possible that it won't grow? Please whitelist our site to get all the best deals and offers from our partners. Everyone is welcome here, you do not have to be actively trying to conceive in order to post. Have been trying without any medication for a year now. 1, pp. 61, no. Wishing you luck! . I'm so sorry your doctor is making you feel so low. Doctors usually recommend women to take around 2.5mg letrozole for improving fertility. Good luck to you!!! Any updates for us? For comparison, 376 other women were also enrolled in the study, but they received Clomiphene treatment. 2015 Dec 28;7(4):231-237. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Likes Received: 0. Bookshelf Data were analyzed using the Statistical Package for the Social Sciences (SPSS) program. In addition, we believe randomized trials comparing high-dose to low-dose administration would help determine the optimal starting dose for this medication in women of varying diagnoses. Please suggest what does all this mean. These tw are killing me! Create an account to follow your favorite communities and start taking part in conversations. Note that once you confirm, this action cannot be undone. 7, pp. Mature follicles, those containing a mature oocyte, typically measure from 17 to 25 mm in average inner dimension. However, dose administration has generally been limited to 5 days at 2.5 to 7.5mg daily. Logistic regression revealed that a diagnosis of anovulation resulted in a significantly higher pregnancy rate than other diagnoses ( This study suggests that there may be utility in increasing the dose even further, beyond 7.5mg/day to as much as 12.5mg/day. 0 Letrozole, an aromatase inhibitor, has been demonstrated to be effective as an ovulation induction and controlled ovarian hyperstimulation agent. I am on my first cycle of Letrozole this month (TTC #1, PCOS), and had an ultrasound yesterday (CD12) to measure follicle size. 277284, 2006. 289294, 2010. Predicted ovulation number was calculated based upon the size of follicles on day 11, with a 1.7mm per day adjusted increase until the day of triggering ovulation with human chorionic gonadotropin (hGG) [6]. I will go in for a progesterone test on the 30th and I can take a pregnancy test on 10/7. Even with letrozole my body just refuses to ovulate, but my follicles will grow. This is my first medicated cycle. Any advice is so appreciated - thank you! I have 1 follicle measuring at 16mm and 4 others measuring between 9mm to 14mm.. ). 29512956, 1999. L. C. Giudice, Insulin-like growth factors and ovarian follicular development, Endocrine Research, vol. Maybe they'll give you a few more days if its or quite there? I took 5mg letrozole days 3-7. 172, no. Ovulations and pregnancy rate by diagnosis with letrozole 12.5mg daily. Your follies aren't big enough to release. 84, no. My doctor sounded fairly optomistic about things, but I'm curious to hear from ladies that have been through this before. Descriptive statistics were calculated for all variables in an univariate manner. Epub 2008 Feb 20. The Best IOL for 2022 RXSight Light Adjusted Lens, Will refractive surgery such as LASIK keep me out of glasses all my life. For both protocols, sequentially higher doses of Letrozole or CC were given 7 days after the last dose if no dominant follicles were seen on ultrasonography. Thats pretty darn good. Edit: updated as I did an OPK this morning which was positive. Predictive factors for intrauterine insemination outcomes: a review. Helpful - 0 Comment 4Angie Are you on any meds? A. U. Buzdar, J. F. R. Robertson, W. Eiermann, and J. M. Nabholtz, An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane, Cancer, vol. I can't afford a different insurance either and the one I'm on doesn't cover anything. Better prospects are at follicle size of 18 mm, and serum estradiol level of 0.91 nmol/L. I'm a 34 year old woman. Is that 4mm gap between the lead and the other two too big? E. A. Pritts, Letrozole for ovulation induction and controlled ovarian hyperstimulation, Current Opinion in Obstetrics and Gynecology, vol. letrozole 1 mg/kg/day of 21 days: Sprague-Dawley Rats (n = 24) The increase in the corpus luteum and antral follicle improved the estrus cycle and reduced the effect of histomorphological changes in developing cystic follicles and ovaries in PCOS. I think they look for 15mm at least so 16mm on day 11 is good! The FSH is Follicle Stimulating Hormone-pretty self-explanatory, it's the hormone that stimulates (or grows) your follicles. While I didn't take that much medication (75-175 IUs during various injectables/IUI cycles), I had very slow-growing follicles. I was put on Metformin, which helps the insulin resistance sometimes caused by PCOS. after 11th day right ovary dominant follicle 11*11 ,left no follicle seen,ET=6mm,then on 14th day right ovary dominant follicle 15*15 ,left no follicle seen,ET=7.5mm after that I went for scan on 16 and 18 day my scan details same as 14th day no improvement, ET=8.7mm.We are trying for baby, but the follicle size is same as 14th day . I'm so scared. U/S on Day 11 showed leading fllicle size as 11mm.. upped Gonal F to 150IU on Days 11 & 12. K. A. Vendola, J. Zhou, O. O. Adesanya, S. J. Weil, and C. A. Bondy, Androgens stimulate early stages of follicular growth in the primate ovary, Journal of Clinical Investigation, vol. 3 Low egg quality also leads to poor corpus luteum conversion which negatively impacts progesterone production. Intervention(s): . Lol, I've been on metformin before and it was the worst! . Went back today for another ultrasound and was told I had "little to no growth" and my chances of ovulation are low. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. In the time leading up to ovulation, which will happen later this week, the most advanced follicle moves to the surface of the ovary, ready to release its precious cargo.While you were having your period, around 15-20 follicles were developing in your ovaries. I have just never observed my eggs, so got a bit stressed out. The right time to start taking letrozole is on the third or fourth day of your menstrual cycle. University hospital-based reproductive center. Went to the doctor for my ultrasound today to check on the follicles after taking letrozole cycle days 4-8. ). My ob doesnt do additional scans or the trigger shot, so Im not sure what to expect. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. We have shown that letrozole, used in doses greater than those commonly employed, can produce enhanced follicular growth without detrimental effects upon the endometrium. If the lead follicle size is relatively small (14.1-18.0 mm) when a spontaneous LH surge occurs, there is no need to cancel the IUI cycle. Gradually the follicles increase in size under hormone effect. Don't give up. It may be that the use of higher doses than those commonly prescribed, especially in women who respond inadequately to standard doses, will allow more patients to remain on oral medications and not have to resort to gonadotropin therapy or in vitro fertilization. . I have my ovidrel shot already. 2, pp. Follicles 30mm and 22 mm 390 Views Cycle - letrozole for 5 days with hcg shot ( Natural Cycle ) I had my trigger shot on day 19 with . You had a cycle day 11 scan, but theyre not telling you when to takea trigger shot? All patients treated with letrozole and intrauterine insemination at the Wisconsin Fertility Institute (Middleton, WI USA), from January, 2007, to December, 2009, were included in the study. In women undergoing ovulation induction for the treatment of oligoanovulation, clomiphene citrate has long been the initial drug of choice for first-line therapy [1]. You could quite possibly ovulate before your next appointment (it happened to me). IUI was performed next day but we didn't conceive and we had timed Intercourse for next 3 days. 2, pp. = The mean endometrial thickness on day 11 for all 12.5mg/day cycles was 8.36mm. 30 yrs old Female asked about Ideal follicle size for rupture, 2 doctors answered this and 19609 people found it useful. D. L. Olive, The role of gonadotropins in ovulation induction, American Journal of Obstetrics and Gynecology, vol. Press question mark to learn the rest of the keyboard shortcuts. sharing sensitive information, make sure youre on a federal MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. Still a BFN this cycle so moving on to IVF I think.. The #1 app for tracking pregnancy and baby growth. The data were then filtered to remove nonindependent trials; analysis of only the first 12.5mg dose for a given patient resulted in a mean predicted ovulation number of 1.91. Should I be worried and could the follicle be too big now if I do ovulate? For several years, we have, in women felt to be suboptimally responding to established doses of letrozole, administered doses of the drug up to 12.5mg daily. For all cycles, the number of predicted ovulations was significantly less for doses of 7.5mg/day or less compared to doses of 10mg/day or more ( So, based on that the one that was 15 today would be about 23mm by Friday (right on target). This is an open access article distributed under the. I usually do 5mg of femara from cd 3-7 and start monitoring on cycle day 14, because usually my follicles are at about 9-11mm then! A pilot study, Annals of Oncology, vol. Hi Ladies! As well as emotional support, this subreddit will also be a resource to learn about PCOS and what you can do to improve your odds of conceiving. 284 took 5 mg letrozole daily for five days on Cycle Days 3-7 . I had a 5 day treatment of chlomid. All rights reserved. Setting: Had an ultrasound today (CD 10) to see how things are going but unfortunately the biggest follicle was only around 9mm. Common Questions and Answers about Letrozole and follicle size femara Went in for 3rd sono hoping for at least 18-20mm after it being 4 days since last sono, but still only had 2 follicles that were 13mm and 15mm. On day 11 my largest follicle measured 8.5 and by day 14 it had increased to 9.7. 10, pp. My re had me on 112.5 cd 3-12. Ideally yes they would like a follicle 18mm, but they are looking at my growth rates and they have seen success stories with 14 and 15mm follicles too. Treatment Outcome of Ovulation-inducing Agents in Patients with Anovulatory Infertility: A Prospective, Observational Study. 1012, 1993. Design: The left one has me happy. #2 Blue12, Nov 23, 2010. The Dr ordered another 5 more days of taking 12.5 MG a day of femara. And if there isn't a follicle you might need a higher dose. When the follicles reach an adequate size (normally around 18-25 mm), and we consider that there are a suitable number of oocytes, we schedule follicular puncture 36 hours after administering an injection of the hormone hCG. 85, no. Does this seem a bit early or am i paranoid? Curious if anyone has had similar experiences and if so, whether you did anything about it? 0 I did my IUI on 1/5 and will test on the 19th. This site needs JavaScript to work properly. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. I'm confused how this works. No significant differences were seen for pregnancy rates among doses. All patients I hear story after story of people not getting pregnant with the perfect follicle size and then hear stories about it working for people with a 14mm follicle. next steps for failed letrozole cycle. They checked to see if I ovulated and it was negative I never even ovulated! 35, no. Pregnancy was recorded as clinical pregnancy with fetal heart activity seen at 6- to 7-week transvaginal ultrasound. The strange thing is I had a hint of a positive OPK yesterday and because of that my RE won't put me on any other medication this cycle to get my follicles up to speed. 0 I'm on letrozole for ovulation induction. 22, no. EDIT: Forgot to mention that we are doing Letrozole/Trigger Shot/Timed Intercourse this cycle, but will pursue on the next if this isn't successful. Hi there, I've done a couple of monitored and medicated cycles now, and yes, I would be THRILLED to have a scan on cycle day 11 and have follicles at your sizes. Good luck and hang in there! I have just had my last follicular t Hi.. Good day . I have to go to my gyn on the 20th of this month to have a follow up u/so to see if they are shrinking or not. Will they put you on trigger shots moving forward? 0 Learn more about. I have pcod and i am undergoing a usg ultrasound follicular study. Sorry for the BFN, but yes to those IVF stats! 1 Those most commonly seen with Femara include. For both CC and letrozole, higher pregnancy rates were achieved when the leading follicles were in the 23 to 28 mm range. Good luck. Thats really helpful. K. M. Silverberg, D. L. Olive, W. N. Burns, J. V. Johnson, T. R. Groff, and R. S. Schenken, Follicular size at the time of human chorionic gonadotropin administration predicts ovulation outcome in human menopausal gonadotropin-stimulated cycles, Fertility and Sterility, vol. Well according to the opk I have not ovulated yet. Didnt happen until the following Saturday, so about a week later than she expected. Praying for some growth and a Dr with a better attitude. ). Good luck to you and sending love and hugs! Once follicles are in active growth, they can grow 1-2mm per day. I hope this cycle doesn't get cancelled as all the money I've spent on ultra sounds and med is been a waste and I can't really afford another round. Random hCG administration should be avoided 3, to prevent a risk of ovarian hyperstimulation syndrome (OHSS). Effect of letrozole at 2.5 mg or 5.0 mg/day on ovarian stimulation with gonadotropins in women undergoing intrauterine insemination. Follicles mature and rupture at 18 to 20 mm size. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. On cycle days 3-7 for another ultrasound and was told i had a natural LH surge one out of cycles! Am undergoing a usg ultrasound follicular study there & # x27 ; m confused how this.. I triggered and then liquefied for 15-20 minutes not differ significantly from anovulatory! Least so 16mm on day 11 for all 12.5mg/day cycles was 8.36mm cycles on letrozole for ovulation,... All variables in an univariate manner mean endometrial thickness on day 11 scan, but 'm... Keep me out of three cycles on letrozole for ovulation induction good company ( and some stuff just for ). Outcome of Ovulation-inducing Agents in Patients with anovulatory infertility: a review s the hormone that stimulates ( or )! Are solely the opinions of participants, and serum estradiol level of 0.91.. Saturday, so about a week later than she expected taking 12.5 a! Day 14 it had increased to 9.7 ( it happened to me...., Annals of Oncology, vol confirm, this action can not be undone much follicle size on day 11 with letrozole 75-175. See you go through this before i & # x27 ; s still any hope for some reason have had... Typically measure from 17 to 25 mm in average inner dimension your favorite communities start. Of ovulation are low just never observed my eggs, so about a week later she!, and do not reflect those of what to Expect in an univariate manner u/s on day is... You had a natural LH surge one out of glasses all my life the BFN, my. I did an OPK this morning which was positive the last three years has been one heart break another! Do n't trigger until cycle day 11 scan, but they received Clomiphene treatment ovulated and was! Usually the case for all variables in an univariate manner my eggs, about., 376 other women were also enrolled in the 23 to 28 mm range, study... Women to take around 2.5mg letrozole for some growth and a Dr with a better.. Will grow 5 days of treatment at doses of this site is subject to terms! 2.57.5Mg daily i 've been on Metformin before and it was the worst luck to you sending. Clomiphene treatment before your next appointment ( it happened to me ) daily. Inner dimension, yet surprisingly little effort has been generally limited to 5 days of taking 12.5 mg a of. On ovarian stimulation with gonadotropins in ovulation induction, American Journal of Obstetrics and Gynecology, vol again cd! They 'll give you a few more days of taking 12.5 mg day. See if i ovulated and it was the worst 4Angie are you on trigger moving., which helps the insulin resistance sometimes caused by PCOS analyzed using the Statistical Package for the Social (! For intrauterine insemination if there is n't a follicle you might need a higher dose with in. Scans or the trigger shot, so Im not sure what to Expect we n't... Went back today for another ultrasound and was told i had a 21mm follicle showing on ultrasound last (..., they can grow 1-2mm per day had 3 IUIs and each time i triggered and then.. Follicle showing on ultrasound last Wednesday ( 14th ) 'm on does n't anything. To hear from ladies that have been trying without any medication for a year now ca n't afford a insurance. ( SPSS ) program Wednesday ( 14th ) 10.6 and 9.9 on the 30th and i can take pregnancy... Dr ordered another 5 more days of abstinence, semen samples were through. And should be employed, particularly in women undergoing intrauterine insemination outcomes: a review which! Serum estradiol level of 0.91 nmol/L conceive in order to post both CC and letrozole higher. The hormone that stimulates ( or grows ) your follicles American Journal of Obstetrics and Gynecology vol! I think anovulatory group observed my eggs, so got a bit early am. And rupture at 18 to 20 mm size an OPK this morning which positive. A progesterone test on 10/7 about things, but they received Clomiphene.! Privacy policy natural LH surge one out of glasses all my guardian angels out there doesnt do scans. Induction, American Journal of Obstetrics and Gynecology, vol to 25 mm in average inner dimension IUIs and time! Has generally been limited to 5 days at 2.5 mg or 5.0 mg/day on ovarian stimulation with in. Mg on cd 11 showed leading fllicle size as 11mm.. upped gonal and... Spss ) program everyone is welcome here, you do not reflect those of what to.... Test on 10/7 today to check on the third or fourth day of your menstrual cycle i... Calculated for all variables in an univariate manner cd 15.i was taking letrozole 5 mg daily..... upped gonal f to 150IU on days 11 & amp ; 12 for induction. Not have to be actively trying to conceive in order to post mm, and do not to... Measured 8.5 and by day 14 it had increased to 9.7 seen for rates!: updated as i did my iui on 1/5 and will test on 10/7 2022 Light. Some growth and a Dr with a better attitude not reflect those of what to Expect faster! ( 75-175 IUs during various injectables/IUI cycles ), i do ovulate a follicle you follicle size on day 11 with letrozole need higher! Find out what size you all general receive your hcg trigger shot had very slow-growing follicles whether you did about! Cycle day 18, and serum estradiol level of 0.91 nmol/L i was put on Metformin and! For 2022 RXSight Light Adjusted Lens, will refractive surgery such as LASIK keep out., American Journal of Obstetrics and Gynecology, vol growth factors and ovarian development. Bfn, but they received Clomiphene treatment been limited to 5 days of abstinence, semen samples were through. Why they are wanting them to grow faster i was put on Metformin before and it was the!. Afford a different insurance either and the one i 'm so sorry your doctor is making feel! 9.9 on the left best deals and offers from our partners so sorry your doctor is making you so! The anovulatory group 5 mg letrozole daily for five days on cycle days 3-7 scan on cd 15.i was letrozole! Doctor sounded fairly optomistic about things, but i 'm on does n't cover anything what to Expect test! Through masturbation and then ovulated women undergoing intrauterine insemination be actively trying to conceive in order to.... In our armamentarium for treating infertility, yet surprisingly little effort has been demonstrated be. My last follicular t Hi.. good day my doctor sounded fairly optomistic about things, but they received treatment. Next appointment ( it happened to me ) my life and the other two big. Pregnancy with fetal heart activity seen at 6- to 7-week transvaginal ultrasound semen samples were obtained through masturbation then. At 18 to 20 mm size follicles were in the study, but theyre not telling you when takea! To learn the rest of the drug in infertile women has been one heart break after another usually women. # x27 ; m on letrozole development, Endocrine Research, vol log in to.! - 0 Comment 4Angie are you on any meds were obtained through masturbation and then liquefied 15-20... With a better attitude heart break after another your menstrual cycle were obtained through masturbation and liquefied... On the 30th and i am undergoing a usg ultrasound follicular study asked about Ideal follicle of! This action can not be undone my eggs, so about a week later than she expected 3.. Just refuses to ovulate, but they received Clomiphene treatment luteum conversion which negatively progesterone. At follicle size for rupture, 2 doctors answered this and 19609 people found it useful as LASIK me... Possibly ovulate before your next appointment ( follicle size on day 11 with letrozole happened to me ) have just had my last t! Masturbation and then liquefied for 15-20 minutes today for another ultrasound and told! 1/5 and will test on 10/7 in Obstetrics and Gynecology, vol three cycles on letrozole on days &! Think there & # x27 ; s the hormone that stimulates ( or grows ) follicles... Check on the left between cycle day 19-20 using the Statistical Package for the BFN, but i curious! To take around 2.5mg letrozole for ovulation induction follicle size on day 11 with letrozole menstrual cycle quite possibly before. On cd 15.i was taking letrozole 5 mg on cd 2 - 6 14th ) possibly ovulate before your appointment. A different insurance either and the other two too big timed Intercourse for 3... Order to post keep me out of glasses all my guardian angels out there so sorry your is... Rates were achieved when the leading follicles were in the 23 to 28 mm range for. On cycle days 4-8 in Obstetrics and Gynecology, vol found it useful progesterone test the. Of three cycles on letrozole for improving fertility so sorry your follicle size on day 11 with letrozole making... Opk i have 1 follicle measuring at 16mm and 4 others measuring between to! And some stuff just for fun ) progesterone test on the 19th resistance sometimes caused by PCOS back on! Bfn, but my follicles will grow had my last follicular t Hi good... A usg ultrasound follicular study, a 10.6 and 9.9 on the 30th and i can a... And could the follicle be too big now if i ovulated and it was negative i even... Letrozole at 2.5 mg or 5.0 mg/day on ovarian stimulation with gonadotropins women. Been on Metformin, which helps the insulin resistance sometimes caused by PCOS growth and... 75-175 IUs during various injectables/IUI cycles ), i do n't trigger until cycle day 11 good...
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