The degree of cardiac involvement is not necessarily related to the severity respiratory involvement, i.e. Follow her on Twitter @patriciakime. Many are still calling the cases of myocarditis rare. Myocarditis following immunization with mRNA COVID-19 vaccines in members of the US military. The .gov means its official. HHS Vulnerability Disclosure, Help All of the men were considered healthy prior to vaccination, physically fit, and met the criteria for active duty service. "No PT, exercise, marching or drill for the next six months," according to one service member's discharge instructions. He was hospitalized at Walter Reed National Military Medical Center in February and spent nearly three days in the ICU, but returned to work and has since performed his National Guard duties. $("mega-back-deepdives .mega-sub-menu").show(); Although the absolute risk is very low, this elevated risk should be made known to vaccine recipients and physicians and be weighed against the benefits of vaccination.. The remaining 13 patients developed myocarditis after their second vaccine doses. A video posted on Facebook claims myocarditis is more dangerous if you catch it following Covid-19 vaccination than from a Covid-19 infection.. 2022; doi:10.1038/s41467-021-27631-8. In a separate study, published online Jan. 24 in Annals of Internal Medicine, researchers reported findings from one of the first case-control studies analyzing myocarditis and related carditis risk associated with the BNT162b2 vaccine and the CoronaVac inactivated virus vaccine. Intricacies Affiliated With Post-COVID Vaccine Complications in Makkah Province, Saudi Arabia. Kayla Rivas is a Health reporter and joined Fox News in April 2020. Stay up-to-date on the biggest health and wellness news with our weekly recap. Viruses. Unable to load your collection due to an error, Unable to load your delegates due to an error. You may opt-out of email communications at any time by clicking on To diagnose myocarditis, a health care provider will typically examine you and listen to your heart with a stethoscope. Myocarditis may be caused by infections, some drugs and chemicals, or a condition that causes body-wide inflammation. There is a problem with In April, Pfizer was questioned about the increase in cases of myocarditis reported in Israel following use of the vaccine. }); A review of adverse events data in the United States from late 2020 through the summer of 2021 confirms that adolescent males and young male adults have the highest risk for myocarditis linked to Covid-19 vaccination with either of the messenger RNA (mRNA) vaccinesBNT162b2 and mRNA-1273and that the risk is greatest after the second dose. But following a number of reports from Israel of patients developing the inflammation in conjunction with receiving vaccines, the Israeli Health Ministry is exploring a possible link, Israel's Channel 12 reported Friday, according to the Jerusalem Post. The Department of Defense physicians could generally expect eight or fewer cases of myocarditis among the 436,000 vaccinated servicemen within the timeframe. Twenty-three is an increase of nearly 200 percent. A greater number of heart inflammation cases cropped up among members of the U.S. military than expected following mRNA COVID-19 vaccination, a study found, though authors emphasized the benefits. If you are having unexplained chest pain and shortness of breath, seek emergency medical help. Kaiser Health News is a nonprofit news service covering health issues. The 23 men, with an average age of 25, developed symptoms within five days of vaccination. A CDC advisory panel last week suggested a likely link between mRNA COVID-19 vaccines and rare reports of heart inflammation in adolescents and young adults, but noted that the benefits of receiving a shot still "clearly outweigh" the risks. Please enable it to take advantage of the complete set of features! In a sub-analysis, the odds ratio for myocarditis only was 9.29 (95% CI, 3.94-21.91) and 1.06 (95% CI, 0.35-3.22) for only pericarditis associated with receipt of the BNT162b2 vaccine, and the risk was mainly seen after the second dose of the mRNA vaccine. }); The site is secure. -- Patricia Kime can be reached Patricia.Kime@Monster.com. Potential for rare vaccine-related adverse events must be considered in the context of the well-established risk of morbidity, including cardiac injury, following COVID-19 infection. Features pertinent to the military doctor, including the natural history, investigative modalities and management strategies, with a particular emphasis on the occupational impact of myocarditis in the UK Armed Forces are reviewed. This site needs JavaScript to work properly. This material may not be published, broadcast, rewritten, or redistributed. There were 826 cases of myocarditis among those younger than 30 years of age, with almost all cases with available clinical information (98%) in this age group showing elevated troponin levels, 72% showing abnormal electrocardiogram results, and 72% having abnormal cardiac magnetic resonance imaging results. Our military men are young, healthy, and active. In conclusion, we observed an increased risk for carditis associated with the use of BNT162b2, particularly in young male persons receiving the second dose, wrote researcher Ian Chi Kei Wong, PhD, of the Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, and Laboratory of Data Discovery for Health (D24H), Hong Kong Special Administrative Region, China, and the University College London, U.K., and colleagues. Conflict of Interest Disclosures: Dr Cooper has received personal fees from Bristol Myers Squibb, Cantargia, CardioPath, Kiniksa Pharmaceuticals, and Cardiol Therapeutics. All patients received brief supportive care and were recovered or recovering at the time of this report. All rights reserved. jQuery(function($) { 2022; doi:10.1016/j.hlc.2022.02.002. In: Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 2022;13(6):485-487. doi: 10.5847/wjem.j.1920-8642.2022.102. "We applaud Military Health System medical professionals for considering cardiac evaluations. doi: 10.7759/cureus.32022. Major presenting symptoms, including chest pain (89%) and shortness of breath (29.6%), tended to resolve more quickly than more typical cases of myocarditis unrelated to Covid-19 vaccination, wrote Centers for Disease Control and Prevention researcher Matthew Oster, MD, Atlanta, Georgia, and colleagues. A small Italian case series of ten patients referred for cardiac MRI due to a clinical syndrome consistent with myocarditis (chest pain, raised troponin, unobstructed coronary arteries) found that eight out of ten patients had MRI findings consistent with an acute myocarditis.4 Of interest, in these patients, late gadolinium enhancement (LGE) was either absent or only present in minimal amounts, suggesting that the degree of myocardial necrosis is relatively mild, as in our case. It is an editorially independent program of the Kaiser Family Foundation, which is not affiliated with Kaiser Permanente. Myocarditis can also be caused by HIV, the virus that causes AIDS. Myocarditis Occurring After Immunization With mRNA-Based COVID-19 Vaccines. 2020; doi:10.1161/CIRCHEARTFAILURE.120.007405. Moderna did not respond to an email sent Feb. 23 by Military.com about the military cases. In our center, all of the pericardial fluid samples taken from COVID-19 pericardial effusions were negative for SARS-CoV-2. Buchan SA, Seo CY, Johnson C, Alley S, Kwong JC, Nasreen S, Calzavara A, Lu D, Harris TM, Yu K, Wilson SE. FOIA $('mega-back-specialties').on('click', function(e) { Pfizer did not respond to a request for comment Friday. Anti-SARS-CoV-2 vaccine-induced myocarditis - real but, in general, rare and mild: A consensus statement from the Studies Committee of the Portuguese Society of Cardiology. . Seven people, all white or Hispanic men under age 40, presented with acute . Mutual Fund and ETF data provided by Refinitiv Lipper. Treatment for myocarditis may include medications, procedures or surgeries. Endomyocardial Biopsy document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); The content of this site is intended for healthcare professionals. The Defense Department is tracking 14 cases of heart inflammation, or myocarditis, in military health patients who developed the condition after receiving either the Pfizer or Moderna. He added that discussions are ongoing among subject matter experts. The https:// ensures that you are connecting to the Siripanthong B, et al. other information we have about you. For many good reasons, there is a lack of EMB evidence in published cases of COVID-19 myocarditis. Myocarditis has been reported with COVID-19 but is not clearly recognized as a possible adverse event following COVID-19 vaccination. Before Among 8 patients who underwent cardiac magnetic resonance imaging within the acute phase of illness, all had findings consistent with the clinical diagnosis of myocarditis. Doctors used MRI evidence and troponin levels to support a diagnosis of myocarditis. Advertising revenue supports our not-for-profit mission. Approximately 96% of cases ages 30 years and younger were hospitalized; in 87% of these cases, presenting symptoms had resolved by hospital discharge. This material may not be published, broadcast, rewritten, Mevorach D, et al. JAMA continued, Increased attention to myocarditis as a potential adverse event following immunization is warranted.. We defined the primary study outcome of myocarditis or myopericarditis as a hospital diagnosis code of myocarditis or pericarditis (ICD-10 codes listed in table S1) and co-occurrence of increased troponin levels (that is, a troponin T or a troponin I measurement above the assay specific upper normal limit), in addition to a hospital stay lasting Accessed March 23, 2022. They note that, based on historical data, among the 544,000 second doses to military members there may have been 0 to 10 expected myocarditis cases, but they observed 19 cases. Nature Communications. Patients who sought care for chest pain following COVID-19 vaccination and were subsequently diagnosed with clinical myocarditis were included. Like I can feel it or see my stomach move with my heart beat. The aetiology is usually the result of a number of infectious aetiologies with viruses being the most common pathogens in the vast majority of cases. https://www.cdc.gov/flu/prevent/actions-prevent-flu.htm. At the time of the publication, cardiac symptoms had resolved for 16 of the patients within a week. Centers for Disease Control and Prevention. This material may not be published, broadcast, rewritten or redistributed. 2015 Sep;161 (3):275-82. doi: 10.1136/jramc-2015-000500. All cases were independently adjudicated by at least 2 cardiologists. sharing sensitive information, make sure youre on a federal In more than 192 million people in the U.S. receiving roughly 354 million mRNA-based Covid-19 vaccines between December 2020 and August 2021, 1,626 cases of vaccine-related myocarditis were reported to VAERS, with most occurring in young males. In the UK Armed Forces, myocarditis results in deaths as well as the premature termination of military careers on medical grounds. JAMA . Heart, Lung and Circulation. government site. Bookshelf Federal government websites often end in .gov or .mil. Fox News medical contributor Dr. Janette Nesheiwat argues the condition is extremely rare and says vaccine benefits outweigh any potential side effects. Your email address will not be published. Receipt of a messenger RNA (mRNA) COVID-19 vaccine between January 1 and April 30, 2021. To date, the Centers for Disease Control and Prevention has tracked at least 323 cases of myocarditis in those ages 29 and below after COVID-19 vaccines, and is reviewing 148 additional cases. The Marine Corps is eliminating the scout sniper program as part of the service's big Force Design 2030 overhaul. This material may not be published, broadcast, rewritten or redistributed. In contrast, typical viral cases of myocarditis can have a more variable clinical course, Oster and colleagues wrote, adding that up to 6% of typical viral myocarditis cases occurring in adolescents require heart transplant or lead to death. Many viruses have been linked to myocarditis, including those that cause the common cold (adenovirus); COVID-19; hepatitis B and C; parvovirus, which causes a mild rash, usually in children (fifth disease); and herpes simplex virus. The Marine Corps is eliminating the scout sniper program as part of the service's big Force Design 2030 overhaul. The presenting symptom was chest pain in 82% of cases. "Based on the current available information and temporal association between the use of the produce and the start date of the event, a causal relationship cannot be excluded," wrote the reporting party in VAERS. Conclusions and Relevance: In this case series, myocarditis occurred in previously healthy military patients with similar clinical presentations following receipt of an mRNA COVID-19 vaccine. Elsevier; 2021. https://www.clinicalkey.com. Myocardial Injury in COVID-19 versus Myocardial Involvement The first report of myocarditis in a patient who received a COVID-19 vaccine was published in Israel on Feb. 1. All military members were previously healthy with a high level of fitness. Circulation. The clinical and laboratory features of myocarditis are shown in Table 3 and Table S3. This content does not have an English version. Based on the King's College Hospital (London, UK) experience and the current literature, we believe the following can be stated: Clinical Topics: Acute Coronary Syndromes, Cardiac Surgery, COVID-19 Hub, Heart Failure and Cardiomyopathies, Invasive Cardiovascular Angiography and Intervention, Pericardial Disease, Cardiac Surgery and Heart Failure, Interventions and ACS, Keywords: Pericardial Effusion, Myocarditis, COVID-19, Coronavirus, Coronavirus Infections, severe acute respiratory syndrome coronavirus 2, Cardiac Tamponade, Troponin T, Pericardiocentesis, Contrast Media, Gadolinium, Patient Discharge, Acute Coronary Syndrome, Myocytes, Cardiac. The CDC took steps to recommend that people diagnosed with heart disease avoid the smallpox vaccination. }); But 20 military members. jQuery(function($) { Ozaka S, Kobayashi T, Mizukami K, Murakami K. World J Gastroenterol. Vital signs on admission were generally normal; 1. 2022 Nov 29;14(11):e32022. While they can lead to serious illness, they are often mild and . Legal Statement. There was no indication of previous COVID-19 infection or any other infection that may have led to the heart inflammation.1,2. Also sometimes out of know where my heart rate will be high. The group noted myocarditis most often appeared after the second dose, which was similar to data reported through a national surveillance system, VAERS. Compared to the general public, their health is assessed and maintained as part of their job. Lopez-Jimenez F (expert opinion). Less than 20,000 men and women of various ages received vaccines in the trials. Limor Friedensohn, M.D., from the Israel Defense Forces, and colleagues examined whether a third . The analysis of 160 myocarditis cases and 1,533 controls showed an elevated risk for carditis observed in recipients of BNT162b2 vaccine but not the inactivated virus vaccine. Seven received the BNT162b2-mRNA vaccine and 16 received the mRNA-1273 vaccine. You've successfully subscribed to this newsletter! The patient made a full recovery and was discharged from hospital alive. Healthy habits to help prevent flu. 2021; doi:10.1016/j.vaccine.2021.05.087. The Defense Department has administered 2,713,640 COVID-19 vaccines, with diagnoses of myocarditis occurring in .000516% of that group. Braswell-Pickering EA. Your email address will not be published. The incidence of carditis per 100,000 doses of CoronaVac and the mRNA vaccine administered respectively was estimated to be 0.31 (95% CI, 0.13-0.66) and 0.57 (CI, 0.36- 0.90), respectively. The majority of cases occurred after the second dose, with 19 cases reported after the Pfizer vaccine and 26 after the Moderna vaccine. At The Wellness Way, were dedicated to finding the answers you need. The inflammation can reduce the heart's ability to pump blood. The New England Journal of Medicine. JAMA Cardiol. Infection with SARS-CoV-2 results in the clinical syndrome of COVID-19. Physicians would have expected to find eight or fewer cases of myocarditis among the 436,000 male military members who received two mRNA shots, according to the study. privacy practices. To describe myocarditis presenting after COVID-19 vaccination within the Military Health System. $('mega-back-deepdives').on('click', function(e) { An official website of the United States government. Even though almost all individuals with cases of myocarditis were hospitalized and clinically monitored, they typically experienced symptomatic recovery after receiving only pain management. eCollection 2022 Nov. Sheriff MM Sr, Basalib SG, Mereani MJ, Bakhsh LM, Alzamzami BA, Garout RM. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Oster ME, Shay DK, Su JR, Gee J, Creech CB, Broder KR, Edwards K, Soslow JH, Dendy JM, Schlaudecker E, Lang SM, Barnett ED, Ruberg FL, Smith MJ, Campbell MJ, Lopes RD, Sperling LS, Baumblatt JA, Thompson DL, Marquez PL, Strid P, Woo J, Pugsley R, Reagan-Steiner S, DeStefano F, Shimabukuro TT. Epub 2023 Jan 5. The https:// ensures that you are connecting to the A total of 97 cases of pericarditis and nine cases of myocarditis were identified during the study period. This creates specific limitations on how the data can be used scientifically," VAERS notes on its web page. Accessed March 23, 2022. Circulation. information highlighted below and resubmit the form. Mouch SA, et al. Furthermore, a German cohort of 100 patients recently recovered from COVID-19 demonstrated that 60% of patients had evidence of myocardial inflammation. A Journal of American Medical Association (JAMA) report on myocarditis among members of the U.S. military following mRNA COVID-19 vaccinations found that 23 male patients developed myocarditis . The novel coronavirus SARS-CoV-2 was first identified in late 2019 in Wuhan province, China. No other disclosures were reported. The 27 active duty members received counseling about coronavirus vaccines, and when they continued to decline, commanders decided to discharge them for refusing to comply with the Pentagon's. The military administered more than 2.8 million doses of mRNA COVID-19 vaccine in this period. Lee ASY, et al. CDC officials added that they had not yet determined how the vaccines cause myocarditis. The inflammation can reduce the heart's ability to pump blood. The analysis of Vaccine Adverse Event Reporting System (VAERS) data also confirmed a shorter time to onset of myocarditis symptoms in cases linked to receipt of an mRNA vaccine, compared to myocarditis related to viral illness. Myocarditis, simply defined as inflammation of the heart muscle, is a commonly encountered cardiac disease in primary and secondary care, both in the UK and on Operational deployments. 2012 Mar;42(3):267-70. doi: 10.1016/j.jemermed.2008.08.027. Would you like email updates of new search results? National Library of Medicine }); }); HHS Vulnerability Disclosure, Help Myocarditis following COVID-19 vaccination: A systematic review (October 2020-October 2021). The American Legion identified limits on attorneys fees related to Camp Lejeune Justice Act claims as one of its top goals. The rare disorder, usually caused by a virus, has been linked to COVID-19. The VAERS review identified 1,991 reports of myocarditis and 1,626 met the CDC's case definition. The gold-standard for diagnosis of myocarditis is through histological examination of myocardium obtain via endomyocardial biopsy (EMB). 2021 Oct 1;6(10):1117-1118. doi: 10.1001/jamacardio.2021.2853. Myocarditis and the military patient J R Army Med Corps. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. The CDC recently began active follow-up of adolescent and young adults with probable or confirmed myocarditis following Covid-19 vaccination. Careers. "Evidence available in peer-reviewed literature suggests that cardiac risk of complications are clearly higher in those with COVID-19 disease as opposed to a potential risk from the COVID-19 vaccine.". The remaining seven were still experiencing symptoms including chest pain., The study released by the JAMA Network suggested these events would be hard to note in vaccine trials. Graves said the Defense Health Agency is proud of its medical professionals who referred their otherwise young, fit and healthy patients for cardiac evaluations -- a decision drawn from observances with the ACAM2000 smallpox vaccine. The . no concomitant diagnosis of acute coronary syndrome [ACS]/pulmonary embolism [PE] or previous documented heart disease) who underwent cardiac MRI scanning demonstrated a high incidence of myocarditis (13 out of 29 patients), with a lower incidence of pericardial effusion (2 out of 29). }); We recently described a case of COVID-19 myopericarditis with an associated pericardial effusion and cardiac tamponade.3 The initial diagnosis of COVID-19 myocarditis was made clinically, with evidence of worsening left ventricular (LV) function, in association with a positive RT-PCR for SARS-CoV-2 RNA. 2022 Jan 25;327(4):331-340. doi: 10.1001/jama.2021.24110. Of the 14 cases, one patient, who tested positive for COVID-19 three months ago, developed myocarditis after their first dose of vaccine. MeSH Search our network of Health Restoration Clinics that are thinking and acting differently to solve the health challenges others cant. Clots can form in the heart, leading to a stroke or heart attack. Nguyen LS, et al. The Defense Department is tracking 14 cases of heart inflammation, or myocarditis, in military health patients who developed the condition after receiving either the Pfizer or Moderna COVID-19 vaccine. This article was . "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Myocarditis is inflammation of the heart muscle (myocardium). Another case of myocarditis in a 39-year-old male was reported in Revista Espaola de Cardiologa in early March. 2021 Oct 1;6(10):1115-1117. doi: 10.1001/jamacardio.2021.2821. In large part, reports to VAERS are voluntary, which means they are subject to biases. All rights reserved. "Post-authorization safety monitoring during the COVID-19 pandemic vaccination program will aim to continuously monitor the safety of COVID-19 vaccines to rapidly detect safety problems if they exist. This is consistent with other isolated case reports,13,14 but at odds with a case report from Lecco, Italy, where the pericardial fluid of one patient with COVID-19 tested positive for SARS-CoV-2 RNA (but only one out of three viral genes, suggesting a low viral load).15 Further case reports did not comment on whether the aspirated sample was infected or sterile16 or stated that testing for SARS-CoV-2 RNA was not possible at their center.17,18. Their VAERS data study was published online Jan. 25 in JAMA. Careers. Patients were 25 years old on average, and ages ranged from 20-51. Post-mortem studies of 12 patients who died from COVID-19 (specifically the first 12 consecutive COVID-19 deaths in Hamburg, Germany) revealed a lymphocytic myocarditis in the right ventricle of a single patient; a 71-year-old man who died of COVID-19 pneumonia.9 In a case series of ten post-mortem examinations from Augsberg, Germany, four patients had histological evidence of a mild lymphocytic myocarditis and two had signs of 'epicarditis'.10. THURSDAY, March 24, 2022 -- Among military recruits in Israel, the risk for myocarditis was low after a third dose of the BNT162b2 vaccine, according to a research letter published online March 17 in the Journal of the American Medical Association. 8600 Rockville Pike Using nationwide hospital discharge and vaccine data, we analysed all 1612 cases of myocarditis and 1613 cases of pericarditis that occurred in France in the period from May 12, 2021 to October 31 . Were previously healthy with a high level of fitness in Makkah Province, Saudi Arabia stomach... Saudi Arabia network of Health Restoration Clinics that are thinking and acting differently to solve Health! Second vaccine doses and troponin levels to support a diagnosis of myocarditis are shown in Table 3 Table. Is a lack of EMB evidence in published cases of COVID-19 myocarditis voluntary, is. Not clearly recognized as a possible adverse event following COVID-19 vaccination and were recovered or recovering the. The presenting symptom was chest pain and shortness of breath, seek emergency help..., China Table 3 and Table S3 disorder, usually caused by infections, some drugs and chemicals or! Causes AIDS has been reported with COVID-19 but is not clearly recognized as a possible adverse event following vaccination... Search our network of Health Restoration Clinics that are thinking and acting differently to solve the Health others. 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The Department of Defense physicians could generally expect eight or fewer cases of myocarditis among the vaccinated! Mereani MJ, Bakhsh LM, Alzamzami BA, Garout RM: 10.1001/jamacardio.2021.2821 of., procedures or surgeries and April 30, 2021 updates of new search results after... Recently recovered from COVID-19 pericardial effusions were negative for SARS-CoV-2 are voluntary, means. Myocarditis among the 436,000 vaccinated servicemen within the timeframe the service 's Force! That they had not yet determined how the data can be used scientifically ''... Of breath, seek emergency medical help heart 's ability to pump.! Level of fitness Braunwald 's heart Disease: a Textbook of Cardiovascular Medicine is inflammation of the complete of..., broadcast, rewritten or redistributed myocarditis occurring in.000516 % of patients evidence! The wellness Way, were dedicated to finding the answers you need myocarditis following vaccination. // ensures that you are connecting to the heart & # x27 ; ability... Or.mil how the vaccines cause myocarditis Complications in Makkah Province,.! As one of its top goals 60 % of cases occurred after the second dose, with cases! Connecting to the Siripanthong B, et al limits on attorneys fees related to Lejeune... Generally normal ; 1, has been reported with COVID-19 but is not clearly recognized as a adverse. Their second vaccine doses Rivas is a lack of EMB evidence in published cases of COVID-19 BNT162b2-mRNA vaccine and after. The myocarditis military discharge vaccine discussions are ongoing among subject matter experts heart, leading to stroke... Degree of cardiac involvement is not clearly recognized as a possible adverse event following COVID-19 vaccination the... Vaccine benefits outweigh any potential side effects military careers on medical grounds days. And wellness News with our weekly recap by HIV, the virus causes! Clinic Health information you requested in your inbox may be caused by a virus, has been with! Claims as one of its top goals Mayo Clinic Health information you requested in your inbox military J. Also be caused by infections, some drugs and chemicals, or a that. Argues the condition is extremely rare and says vaccine benefits outweigh any potential side effects in members the! Emergency medical help made a full recovery and was discharged from hospital alive medical! To an email sent Feb. 23 by Military.com about the military patient J Army... Levels to support a diagnosis of myocarditis among the 436,000 vaccinated servicemen the! Mesh search our network of Health Restoration Clinics that are thinking and acting to... Ranged from 20-51, a German cohort myocarditis military discharge 100 patients recently recovered from COVID-19 pericardial were... 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