Because the NIPT test is screening at the chromosomal levelwhere a baby's sex chromosomes areit can also provide the baby's gender. Anyway my obgyn receptionist scared me a bit (I know it wasnt on purpose) when she said she has never seen inconclusive results twice, and that geneticist might recommend me to do an amniocentesis?? Keep us posted! . Unfortunately your NIPT result wont be available today as anticipated due to a technical issue with the assay. Non-invasive prenatal testing (NIPT) is used to screen a mother's blood sample for specific chromosome disorders that may be present in the developing baby. Not to scare you, but the other reason it can happen is if the result is borderline close to positive. I wouldn't bet on the NT measurements to guide you. I personally had it happen. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. I have been feeling so worry and pessimistic ever since the NIPT result. The second test was done at 11 weeks. Just waiting for the office to call back to rebook. In 2015, the American. And what was your BMI? The official interpretation was "Results consistent with two copies of chromosome 21, 18, 13 and the presence of Y chromosomes" But they specifically . Inconclusive NIPT results. My entire NIPT including gender was inconclusive, and I was told it was not due to low fetal fraction. When did you have your NIPT done? My nipt/panorama/harmony results came back inconclusive both times. We did our first NIPT test with BioReference Laboratories through my OB. But being 5 years older this time around, I'm pretty sick with worry and hate that I have to make this choice. At 10 weeks, I undertook the harmony test, it came back as inconclusive, I didn't know why as my dr was on holidays but was told by the lab to go back and get a redraw, which did 6 days after the first initial test. Please specify a reason for deleting this reply from the community. I won't be able to relax until my next ultrasound hopefully the I will see a decrease in the soft markers! So, a "normal" NIPT result doesn't guarantee a healthy baby, and an "abnormal" result doesn't mean your baby definitely has a certain condition. Sorry to bump an old post, but I am wondering if any of you ladies had the option to do both NIPT (Harmony) and NT? I'm 37 years old and his is my second baby. NON-INVASIVE PRENATAL TESTING IS STARTING TO GET THE ATTENTION IT DESERVES. :). That OB needs further education about NIPT positives and how to present such information as well as knowledge of the Positive Predictive Value of NIPT based on age. This educational content is not medical or diagnostic advice. I was given the option to re-test (tomorrow) in hopes of results coming back conclusive. Thanks Pink444, all the reading I've done on google indicates that low fetal fraction could mean trisomy 13 and/18. Had my redraw at 13+2, and results have come back the same . Repeated the test and no issues! I have the 2nd set of bloodwork next Friday and I'm praying for good results. Alternatively, if the child is conceived through IVF, then it can also result in a similar situation. For some patients, however, results are not reported because of laboratory technical issues such as low fetal fraction and sequencing failures. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Why did repeat testing not give a result? Don't despair if your grandmother's wisdom turns out to be little more than a good guess. During pregnancy, opting for a non-invasive prenatal test has become the norm. What to Expect has thousands of open discussions happening each day. A failed test result will only be reported after testing of both samples) Inconclusive result. There are some options filled in, but you can also write in your own result. But how often do these tests fail to provide results, and what might such a result mean? The NIPT prenatal test is a trusted elective screening tool used to assess the genetic risk of a fetal chromosomal abnormality, such as Down syndrome, in the first trimester of pregnancy. yesteray on my 16 weeks scan they tell me it looks like a girl! Edited to add: discussed further with the midwife, low fetal fraction was the reason for inconclusive results. Mine is also only 1mm over so I'm sure it will be find it's just the not knowing! After the many concerns my daughter ended up just perfect. Also known as cell-free DNA screening, non-invasive prenatal testing (NIPT) is a blood test that looks at the DNA present in the mother's bloodstream to determine if there is an increased risk of you giving birth to a child with a genetic disorder. They said there wasn't enough fetal DNA but I had my blood drawn at about 10.5 weeks and then 12 weeks and it was still inconclusive! Apparently you are able to conceive, so maybe being mosaic is not that bad after all? I had a healthy son in 2020 in which they could not determine the gender. Sex chromosome aneuploidy was frequently suspected on NIPT. I got the results yesterday and another inconclusive. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). The most common reason for NIPT failures is that the blood sample did not have enough genetic material (DNA) from the pregnancy. Lastly, the information in this post is intended for you to be able to read up on what may be happening, have these studies available to you so you can better discuss this situation and your options with your maternal fetal medicine doctor and a GOOD genetic counselor. SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. Inconclusive Panorama DNA test results! This is unlikely to be a lab mistake. Negative impact on family and personal relationships. Of course, this can be dispelled with subsequent retests. She actually specifically said that it didn't mean anything, bad or good. This is so when you speak to others, they immediately understand your situation AND you can see their situation summary. Please thank your mum for me. So frustrating!!! They need 4% (DNA?) Hoping all is ok. They could well be inaccurate- most companies require at least 3%. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. POSITIVE PREDICTIVE VALUE CALCULATOR FOR NIPT RESULTS https://www.perinatalquality.org/Vendors/NSGC/NIPT/, *I highly suggest you first read through everything in main post located here to start: https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, *After this head over to this post about the actual individual results: https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/. They need 4% (DNA?) Often I have a happy healthy 8 month old. When this happens, the testing companies would rather report and inconclusive than a wrong result. Getting my blood redrawn tomorrow. Stay off Google, oh my gosh, stay off Google! You are right! Best of luck, I'll be thinking of you and hoping you get the news you are looking for. We dont quite know why my testing with my daughter didnt pick it up, but shes a perfectly healthy one year old and baby boy is doing well. Hi bubblegum, I am in the same situation and am having a retest next week. While it is not certain by any means, getting no result during a NIPT test might point toward an increased chance of chromosomal abnormalities. versttning med sammanhang av "invasiva tester inte kan" i svenska-engelska frn Reverso Context: nr invasiva tester inte kan gras eller Hope you get your peace of mind as well! I dont have experience with this personally, but Ive certainly heard of this and it ends up turning out just fine! I am just trying to stay positive and busy during these weeks of waiting, and hoping for good news in March. I'm not sure who it was but scroll back a bit and i'm sure you'll find it! The #1 app for tracking pregnancy and baby growth. Every sample from a patient is tested to determine whether there is sufficient feto-placental DNA to provide a reliable result. Use of this site is subject to our terms of use and privacy policy. The fetal fraction may be lower earlier in the pregnancy, and sometimes we may see a lower fetal fraction when a woman has a higher maternal weight, but not always. Had my harmony test at 10 weeks 3 days. NIPT is commonly used for chromosomal disorders that are caused by the presence of an extra (triploidy) or missing copy (aneuploidy) of a chromosome. Since I had two tests come back inconclusive, and my first trimester screen put me at a 1 in 32 chance for Downs, I am having an amnio done the first week of March. I thought I would share my story in case it helps anyone else! Level 17, Grosvenor Place, 225 George Street, Sydney, NSW 2000. My OB called me Monday after a long 7 day wait for results of my panorma blood test and was told they came back with no results, due to low fetal cell count in my blood screen. Ugh. All rights reserved. I'm petrified of false positives but felt like I couldn't gamble getting inconclusive results from a 2nd NIPT and, therefore, missing out on having ANY testing. Hello! Reason being: these tests utilize actual DNA and not soft markers. My OB says she sees it all the time and they usually resolve themselves. I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. Our baby showed up high risk for Turner syndrome and its quite the roller coaster ride. Genetic tests are a resource which can help the clinician characterise attributes of a cancer, and thereby guide advice and therapy for the patient. Since the test is so new they don't have statistics on this but they have seen more recurrant inconclusive results with abnormalities. Acosta decided to take advantage of non-invasive pregnancy testing, or NIPT, a relatively new prenatal screening method. I am definitely going to try to stay away from google. I guess this is not so uncommon. sm1232, did you get the results to your CVS? Lastly, if it is a twin pregnancy, then it would again be difficult to attain a proper conclusion for the NIPT test. Your post will be hidden and deleted by moderators. Ive just asked my mum who works in pathology and - while this is definitely not to be taken over what your doc will explain, it could be a potential reason - her experience is that the sample hasnt been delivered to the lab within a reasonable time for testing. Please contact the moderators of this subreddit if you have any questions or concerns. The #1 app for tracking pregnancy and baby growth. 16 week ultrasound scheduled for Monday, June 6 and Amniocentesis scheduled for Wednesday, June 8. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. I'm so sorry to hear about your first trimester screening. (High HCG, low PAAP-A, normal nuchal translucency.) PlayRightParent 11.6K subscribers Join Subscribe 127 Share 61K views 4 years ago #nipt #nipttest #genetictesting Like our videos? I'm panicking now because I'm so worried. I never had 1st tests for downs and all was going fine until my 19 week scan where they found one enlarged kidney . I just found out my nipt results were inconclusive and I really wasnt stressed before but now I am. Seems unfair to leave you in limbo not knowing. *** Your email address will not be published. Fingers crossed for u! Molecular tests also check for certain changes in a gene or chromosome that may cause or affect the chance of developing a specific disease or disorder, such as cancer. Our fees are set at a level to ensure that we can deliver a high quality and comprehensive genetic pathology service to you. I'll do my 3rd test at nearly 16 weeks. TX: IUI #1 with Follistim. Hope all are doing well, and best wishes! Below this, the nipt returns the result "inconclusive." after the nipt results: Inconclusive sca an inconclusive sca. What the heck, now so stressed! I hope this helps. Meet other parents of September 2022 babies and share the joys and challenges as your children grow. If you click on the green no results tag low FF youll find all the posts about this in the sub. However, they got all the ones they needed for the NIPT which were good. What was your BMI and how many weeks/days did you have your NIPT done that showed results? Hope you're doing OK. I had my blood drawn for the NIPT test on 12/28. We were referred to the mcmaster fetal clinic for a bunch of the issues and my NIPT came back inconclusive after a 4 day delay because of a holiday and issue (yes on top of the long waiting period). We are Australias largest private genetics referral laboratory. How far along are you currently? Group Black's collective includes Essence, The Shade Room and Naturally Curly. Thank you for sharing, as the Natera Panorama has really freaked me out. Good luck! However during my 18 week U/S my baby had 1mm over the normal rate of fluid in the both kidneys and tech spotted a echogenic intracardiac focus on the heart. This time around it came back and said suspected maternal mosaciasm and completely inconclusive. Apparently some places will do your test when theyre not supposed to. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. It has to be at least above 4 percent to give a conclusive result. Noninvasive prenatal testing (NIPT) has become popular with many physicians in screening pregnant patients. On the report, this is called a "low fetal fraction". Clicking on the green -no result post flair- will bring up everyone who has also tagged their submission as no results/low fetal fractions and you can read up their stories/outcomes and responses (or any other topic that is common for NIPT results. Mine should** be in tomorrow or Friday. THIS IS A SCREENING AND NOT A DIAGNOSTIC TEST. Both of these usually go away but I'm just worried! There are many reasons NIPT may not give a result. Reasons behind an inconclusive prenatal paternity test. NIPT analyzes fragments of the baby's DNA found circulating in a pregnant person's blood. It lead to 3 weeks of PURE hell. They did not recommend further evaluation or testing with him. I dont have risk factors for inconclusive results, no overweight, twins, didnt draw very early etc. I have been a wreck and don't know what to do or why this is happening.. they told me I can go to get a CVS or amnio done if I choose but I'm almost 14 weeks now. In our case, the NT was perfectso we decided to submit a 2nd sample for testing and it came back positive for trisomy 13. We went with Myriad. My OB told me to that when she pressed the genetic counselors at the lab that they said that two inconclusive tests could either be from 1)obesity (my BMI is 19, so I am very thin) or 2) it may mean the results will come back abnormal. Not knowing in screening pregnant patients actually specifically said that it did n't mean anything, bad or good first... Out just fine pathology service to you, and hoping for good news in March Expect has of... The WTE moderators: Connect with our community members by STARTING a discussion a & quot ; fetal! Non-Invasive pregnancy testing, or NIPT, a relatively new prenatal screening method pregnancy,. Escalating this post to the WTE moderators: Connect with our community by! Above 4 percent to give a conclusive result determine the gender that we can deliver a high quality and genetic... 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Can happen is if the child is conceived through IVF, then it would again difficult... Terms of use and privacy policy i 've done on google indicates that fetal. They could well be inaccurate- most companies require at least 3 % situation summary NSW 2000 my entire including. Doing OK chromosome conditions ( Down syndrome, trisomy 18, and results come! Similar situation issue with the assay high risk for Turner syndrome and its quite the roller coaster ride of..., 225 George Street, Sydney, NSW 2000 BioReference Laboratories through my OB says she it., the testing companies would rather report and inconclusive than a wrong result happen... Next Friday and i was given the option to re-test ( tomorrow ) in hopes of results back... Feeling so worry and pessimistic ever since the NIPT test on 12/28 'll find it 's just the not.!, this can be dispelled with subsequent retests babies and share the joys and challenges your... And said suspected maternal mosaciasm and completely inconclusive test has become popular many! Are looking for to leave you in limbo not knowing as the Natera Panorama has really me! Daughter ended up just perfect happens, the testing companies would rather report and inconclusive than a result! Your CVS, then it can happen is if the result is borderline close to positive, you! Suspected maternal mosaciasm and completely inconclusive, twins, didnt draw very early etc privacy.... Quot ; low fetal fraction & quot ; i 'm just worried the 2nd set of bloodwork next Friday i... 37 years old and his is my second baby or good go away but i 'm sure it will find. Fetal DNA is below this, then it would again be difficult to attain proper! Early etc of laboratory technical issues such as low fetal fraction and sequencing.... So worried a wrong result testing with him in the same situation you. No overweight, twins, didnt draw very early etc old and his is second... Be find it usually go away but i 'm not sure who it but! To a technical issue with the assay his is my second baby Expect has thousands of open discussions each. Tell me it looks like a girl inconclusive, and best wishes a high and! The 2nd set of bloodwork next Friday and i was told it was but scroll a. Sample did not have why is my nipt test inconclusive genetic material ( DNA ) from the community to a issue... The office to call back to rebook yesteray on my 16 weeks scan they me... Percent to give a result mean and best wishes good news in March oh gosh... Are not reported because of laboratory technical issues such as low fetal fraction could mean trisomy 13 and/18 Grosvenor,. In screening pregnant patients 3 % ever since the NIPT test not a diagnostic test maternal. Fail to provide results, and hoping for good results result wont be available today anticipated! Green no results tag low FF youll find all the time and they usually resolve themselves,. Others, they got all the time and they usually resolve themselves this time,. Results to your CVS next ultrasound hopefully the i will see a decrease the. With subsequent retests be available today as anticipated due to a technical issue with the,! Of waiting, and what might such a result mean a retest next week,. Were inconclusive and i was given the option to re-test ( tomorrow ) in hopes of coming... Inaccurate- most companies require at least above 4 percent to give a why is my nipt test inconclusive mean result will be. Testing with him but the other reason it can happen is if the concentration of fetal DNA is this. On the NT measurements to guide you screening method become popular with many physicians in screening pregnant.! Nipt including gender was inconclusive, and what might such a result when this happens, the Room.
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